SYNTHESIS OF THIAZOLOQUINOLINE SCHIFF BASES AS POTENTIAL ANTIBACTERIAL AGENTS

Abstract

The novel synthetic methods of heterocyclic Schiff bases are attracting the science society through their potential bio and medicinal applications which motivated us to develop new quinoline Schiff bases using 2-amino-4(p-methylphenyl)-thiazole as starting precursor. All the newly synthesized Schiff bases by a simple condensation reaction are characterised and confirmed using FT-IR, 1 H-NMR, 13 C-NMR, Mass and CHNS elemental analysis techniques. Titled compounds are screened for their antibacterial activity against different Gram-positive and Gram-negative bacterial strains using disc dilution method. Among the synthesized compounds (2-amino-4(p-methyl phenyl)-thiozole and 8-methoxy and naphthyl substituted quinoline Schiff bases have shown remarkably enhanced activity against Escherichia coli, Salmonella typhi and Staphylococcus aureus. The minimum inhibition concentration (MIC) values observed from (25-32)µg/mL for three different bacterial strains.