BIOSENSORS BASED ON METAL-ORGANIC FRAMEWORK (MOF): PAVING THE WAY TO POINT-OF-CARE DIAGNOSIS

Abstract

Metal-organic frameworks (MOFs) are recent versatile materials that have found application in gas storage, electrochemical sensors, drug delivery vehicles, and so on. MOFs have become an exotic class of material candidates due to their limitless combination of metal ions and organic ligands. This provides a wide range of inherent functionalities. The infinite crystalline lattice, porosity, and high surface area of MOFs have made them an important tool to sense various analytes of interest. The pore size of MOFs can also be tuned by employing organic ligands with many functional groups. The promising qualities of MOFs have extended its application in the detection of various contaminates in edible products and also as biosensors. This chapter discusses MOFs as biosensors and examines quantitative detection including the specific association of an analyte with an MOF and the utilization of both primitive and synthetic MOFs for occasional visual detection and direct in vitro or in vivo estimation.