STRUCTURAL CHARACTERIZATION, DNA INTERACTION AND PHARMACOLOGICAL EVALUATION OF CU (II), CO (II), NI (II), FE (II) DIHYDRATE COMPLEXES DERIVED FROM PYRIDINE-2,5-DICARBOXYLIC ACID AND 2-METHYLIMIDAZOLE AS ORGANIC MOIETIES

Abstract

The study of Metal organic coordination polymers is one of the most emerging areas of research in coordination chemistry because of their wide technological and interesting applications in pharmacology, sensor studies, catalysis, hydrogen storage devices, magnetic and NLO materials, ion exchange adsorption, metallic conductivity and luminescence studies. In this research work, microcrystalline transition metal [Cu (II), Co (II), Ni (II) and Fe (II)] complexes of Pyridine-2,5-dicarboxylic acid and 2-Methylimidazole as organic moieties were synthesized and analyzed for DNA interaction, biological properties like anti-cancer, anti-oxidant and anti-microbial activities. Structural characterization were studied using Fourier Transform-Infra Red spectroscopy (FT-IR), X-ray Diffractions (XRD), Ultraviolet-Visible spectroscopy (UV–VIS), Field Emission Scanning Electron Microscopy (FE-SEM), Energy-Dispersive X-Ray analysis (EDX), Cyclic voltammetry (CV) and Thermo Gravimetric Analysis (TG-DTA). The copper complex demonstrates superior biological activity compared to alternative complexes, exhibiting antioxidant, antibacterial, and anticancer properties. From cytotoxicity results, it's evident that complexes (1–4) possess the capability to inhibit tumor cell growth while sparing normal cells, attributed to the metal atoms' strong affinity for cancer cells.