Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/5121
Title: ANTIBACTERIAL ACTIVITY OF RHIZOME OF CURCUMA AROMATICA AND PARTIAL PURIFICATION OF ACTIVE COMPOUNDS
Authors: Revathi, S
Malathy, N S
Keywords: Curcuma aromatica
antibacterial activity
crude extract
germacrone
germacrone
Issue Date: Nov-2013
Publisher: Indian Journal of Pharmaceutical Sciences
Abstract: The hexane extract of Curcuma aromatica, a plant belonging to the family Zingiberaceae was tested on 10 bacterial strains (clinical isolates and standard strains). Agar diffusion method was adopted for determining the antibacterial activity of the extract. The hexane extract was found to be active against all Gram-positive strains tested, but inactive against Gram-negative strains. The minimum inhibitory concentration and minimum bactericidal concentration were determined and found to be 539 μg/ml. The phytochemical analysis of hexane extract by gas chromatography mass spectrometry revealed the presence of 13 compounds. The crude hexane extract was partially purified by thin layer chromatography. The zone showing good antibacterial activity was analysed further by gas chromatography mass spectrometry, UV/Vis spectrophotometry and Fourier transform infrared spectroscopy, which indicated the probable presence of germacrone.
URI: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928740/pdf/IJPhS-75-732.pdf
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