Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/5128
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMurugesan, Mano-
dc.contributor.authorJinbo, Song-
dc.contributor.authorWenjian, Zhu-
dc.contributor.authorHu, Zhou-
dc.contributor.authorJunhao, Zhang-
dc.contributor.authorPalaniappan, Meena-
dc.contributor.authorAihua, Yuan-
dc.date.accessioned2024-09-06T11:29:10Z-
dc.date.available2024-09-06T11:29:10Z-
dc.date.issued2021-02-
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053610/pdf/RA-010-D0RA01852J.pdf-
dc.description.abstractGlobally, the pharmaceutical industry is continuously driven in search of new anticancer drugs due to increasing rate of cancer patients. Clinical trials of Cisplatin has been explored, however, usage of Cisplatin as a drug is limited due to its various side effects, hence, alternative to platinum based complex drugs and its analogues are needed. Iridium complexes have been attracted widespread interests by virtue of their pharmacological and photo-physical properties; however the less number of complexes was reported in the literature. In this article, a new series of novel Iridium (III) complexes were synthesized using substituted quinoline Schiff Base (SB) ligands and characterized by spectroscopic techniques. The in- vitro cyto-toxicity assay showed that the Iridium (III) complex activity is equal to standard Cisplatin. In addition, computational docking studies have shown that the prominent binding sites for synthesized complexes against HeLa cell lines, which is comparable with standard Cisplatin drugs and other Ruthenium complexes.<br />.en_US
dc.language.isoen_USen_US
dc.publisherRoyal Society of Chemistryen_US
dc.subjectIridium complexesen_US
dc.subjectMolecular dockingen_US
dc.subjectDNA nickingen_US
dc.subjectQuinoline Schiff Baseen_US
dc.titlePOLYMER-ASSISTED SYNTHESIS AND APPLICATIONS OF HYDROXYAPATITE (HAP) ANCHORED NITROGEN-DOPED 3D GRAPHENE FOAM-BASED NANOSTRUCTURED CERAMIC FRAMEWORKen_US
dc.typeArticleen_US
Appears in Collections:b) Free Full Text



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.