Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/5183
Title: IMPROVING THERAPEUTIC POTENTIAL IN BREAST CANCER VIA HISTONE DEACETYLASE INHIBITOR LOADED NANOFIBRILS
Authors: Praveetha, Senthilkumar
Bhaskar, Gogoi
Swati, Smita Dhan
Ramesh, Subramani
Charumathi, Pushparaj
Ayyavu, Mahesh
Keywords: SAHA
apoptosis
breast cancer
histone deacetylase inhibitors
nanofibrils
β-lactoglobulin
Issue Date: Apr-2024
Publisher: Wiley Periodicals LLC
Abstract: Epigenetic modifications play a significant role in cancer progression, making them potential targets for therapy. Histone deacetylase inhibitors have shown promise in inhibiting cancer cell growth, including in breast cancer (BC). In this research, we examined the potential of using suberoyl anilide hydroxamic acid (SAHA)-loaded β-lg nanofibrils as a drug delivery system for triple-negative BC cell lines. We assessed their impact on cell cycle progression, apoptosis, levels of reactive oxygen species, and mitochondrial membrane potential in cancer cells. The combination of SAHA and β-lg nanofibrils demonstrated enhanced efficacy in inhibiting cell growth, inducing cell cycle arrest, and promoting apoptosis (43.78%) compared to SAHA alone (40.09%). Moreover, it effectively targeted cancer cells without promoting drug resistance while using a low concentration of the nanofibrils. These findings underscore the promising potential of nanofibril-based drug delivery systems for BC treatment.
URI: https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/ddr.22172
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