Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/5306
Title: ANTIBACTERIAL AND ANTICANCER ACTIVITY (PANC-1) OF GREEN SYNTHESIZED COPPER OXIDE NANOPARTICLES FROM CATHARANTHUS ROSEUS
Authors: Karthika, S
Kanchana, P
Prabha Devi, B
Shanmuga Sundari, S
Keywords: Green synthesis
copper oxide nanoparticles
Catharanthus roseus
antibacterial
Issue Date: 2024
Publisher: Taylor and Francis Ltd
Abstract: Copper oxide nanoparticle was biosynthesized using the petals of Catharanthus roseus, and it was found to exhibit anticancer activity in a human pancreatic cell line (PANC-1). The obtained nanoparticles were characterized using XRD, FTIR, FESEM, and TEM techniques. XRD confirms the coexistence of CuO and Cu2O nanoparticles with an average grain size of 15 nm. FTIR spectra possess bands that indicate the formation of copper oxide nanoparticles. FESEM and TEM show spherical shape morphology with an average particle size of 19.6 nm to 32.6 nm. The synthesized copper oxide nanoparticles were tested for antibacterial activity, and the gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa showed a better zone of inhibition than standard streptomycin. The copper oxide nanoparticle was tested for anticancer activity in the PANC-1 line, and the results confirm that cells undergo cell shrinkage in the cytoplasm, which suggested the cytotoxic behavior. The viability of cells was evaluated by an inverted phase contrast microscope followed by the MTT assay method.
URI: https://doi.org/10.1080/24701556.2023.2228777
ISSN: 24701556
Appears in Collections:2.Article (96)



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