Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/1152
Title: STRUCTURAL, THEORETICAL INVESTIGATIONS AND BIOLOGICAL EVALUATION OF CU(II), NI(II) AND CO(II) COMPLEXES OF MERCAPTO-PYRIMIDINE SCHIFF BASES
Authors: JoneKirubavathy S
Chitra S
Keywords: Mercaptoschiff base complexes
DNA cleavage
HOMO-LUMO
DNA binding
Biological activity
Issue Date: 5-Nov-2017
Publisher: Elsevier
Abstract: A new series of transition metal complexes of mercapto pyrimidine Schiff base complexes has been studied and characterized using various spectral techniques like single crystal XRD, FT-IR, electronic, EDX and TGA. The molecular properties of the ligand and the complexes have been derived from HOMO-LUMO calculations using Gaussian software. The biological evaluation of the ligands and the complexes has been studied and compared. The DNA binding studies of the complexes has been carried out and the binding constants are in the order of 104 M−1. The DNA cleavage activity of the complexes proves the mechanism of cleavage is through non-hydrolytic pathway.
URI: https://www.sciencedirect.com/science/article/abs/pii/S002228601730950X
http://localhost:8080/xmlui/handle/123456789/1152
ISSN: 0022-2860
Appears in Collections:International Journals



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