CRYSTALLIZATION OF 1, 4-CYCLOHEXANEDICARBOXYLIC ACID BRIDGED TETRA NUCLEAR CU(II) COMPLEX CONTAINING N–N CHELATING LIGAND – CRYSTAL STRUCTURE, ANTIMICROBIAL, ANTIOXIDANT, CYTOTOXICITY AND ELECTROCHEMICAL STUDIES

Abstract

A crystalline Cu(II) complex [Cu4(CHDA)2(phen)4(H2O)2(DMF)2].(NO3)22H2O was assembled by 1, 4-cyclohexanedicarboxylic acid (CHDA) and 1, 10-phenanthroline (phen) under ambient conditions. The single crystal x-ray diffraction studies evidenced the crystallization of the title complex (CCP) in triclinic crystal system with P-1 space group with V = 1996.94(14) Å3. The orientation of CHDA, packing nature, hydrogen bonding, π–π stacking stabilizing the structure of the complex are studied. FT-IR, SEM, TG-DSC, ESR and electronic absorption analysis were carried out. The gll and g⊥ values calculated from ESR curve confirm square pyramidal geometry of the Cu atom. Antimicrobial activity of the complex against Escherichia coli (Gram negative) and Staphylococcus aureus (Gram positive) was tested. The ability of complex toward free radical scavenging was estimated by DPPH assay. The cytotoxicity of the complex against cervical (HeLa) and lung adenocarcinoma (A549) cancer cells was estimated and IC50 values are reported. The CV measurements concluded the capability of the complex to act as an effective electro active material in the development of electrochemical sensors.