SYNTHESIS, CHARACTERIZATION OF C-ZN/PD-NP AS POTENTIAL NANOCOMPOSITES AGAINST HUMAN LUNG CANCER CELLS (A549) AND PATHOGENIC MICROORGANISMS

Abstract

Palladium wrapped ZnO nanocomposites synthesis through carrageenan were made as bimetallic nanocomposites (C-Zn/Pd-Np) and their antibacterial and anticancer efficacy were assessed under in vitro condition. Further, they were physico-chemically characterized. The metal complex was subjected to characterization by a range of physico-chemical techniques, encompassing scanning electron microscopy (SEM), X-ray diffraction (XRD), and infrared spectroscopy (FT-IR). According to the X-ray diffraction (XRD) study, the bimetallic nanocomposites exhibit a higher degree of crystallinity. The antibacterial activity of the nanocomposites was assessed using Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis, and Escherichia coli as test organisms. The outcomes demonstrated significant antibacterial efficacy against all of the investigated pathogens. The antiproliferative effectiveness of the nanocomposites against A549 cancer cell types are significantly enhanced with an increased concentration. It also resulted in cell cycle arrest, apoptosis, and necrosis found in bimetallic nanocomposites treated cells. In conclusion, (C-Zn/Pd-Np) has notable antibacterial action and is effective against at inhibiting the growth of lung cancer cells. According to this present study, C-Zn/Pd-Np may be useful for the effective clinical management of Human pathogens and lung cancer cells.