Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/5128
Title: POLYMER-ASSISTED SYNTHESIS AND APPLICATIONS OF HYDROXYAPATITE (HAP) ANCHORED NITROGEN-DOPED 3D GRAPHENE FOAM-BASED NANOSTRUCTURED CERAMIC FRAMEWORK
Authors: Murugesan, Mano
Jinbo, Song
Wenjian, Zhu
Hu, Zhou
Junhao, Zhang
Palaniappan, Meena
Aihua, Yuan
Keywords: Iridium complexes
Molecular docking
DNA nicking
Quinoline Schiff Base
Issue Date: Feb-2021
Publisher: Royal Society of Chemistry
Abstract: Globally, the pharmaceutical industry is continuously driven in search of new anticancer drugs due to increasing rate of cancer patients. Clinical trials of Cisplatin has been explored, however, usage of Cisplatin as a drug is limited due to its various side effects, hence, alternative to platinum based complex drugs and its analogues are needed. Iridium complexes have been attracted widespread interests by virtue of their pharmacological and photo-physical properties; however the less number of complexes was reported in the literature. In this article, a new series of novel Iridium (III) complexes were synthesized using substituted quinoline Schiff Base (SB) ligands and characterized by spectroscopic techniques. The in- vitro cyto-toxicity assay showed that the Iridium (III) complex activity is equal to standard Cisplatin. In addition, computational docking studies have shown that the prominent binding sites for synthesized complexes against HeLa cell lines, which is comparable with standard Cisplatin drugs and other Ruthenium complexes.<br />.
URI: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053610/pdf/RA-010-D0RA01852J.pdf
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